Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1997-02-03
1998-07-14
Zitomer, Stephanie W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 435911, 435912, 435913, 536 221, 536231, 536243, 536 2431, 536 2432, 536 2433, 514 44, C07H 2104, C07H 2102, C12Q 168, C12P 1934
Patent
active
057806101
ABSTRACT:
Methods are provided for substantially reducing background signals encountered in nucleic acid hybridization assays. The method is premised on the elimination or significant reduction of the phenomenon of nonspecific hybridization, so as to provide a detectable signal which is produced only in the presence the target polynucleotide of interest. In addition, a novel method for the chemical synthesis of isoguanosine or 2'-deoxy-isoguanosine is provided. The invention also has applications in antisense and aptamer therapeutics and drug discovery.
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Collins Mark L.
Horn Thomas
Sheridan Patrick J.
Urdea Michael S.
Warner Brian D.
Barovsky Kenneth
Blackburn Robert P.
Fredman Jeffrey
Goldman Kenneth M.
Zitomer Stephanie W.
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