Reduction of matrix interference for MALDI mass spectrometry...

Radiant energy – Ionic separation or analysis – With sample supply means

Reexamination Certificate

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C250S287000, C250S292000, C250S294000, C250S299000, C250S300000, C428S416000, C428S418000, C428S420000, C428S428000, C428S429000, C428S432000, C428S433000, C428S434000, C428S435000, C428S438000, C428S442000, C428S445000, C428S446000, C428S447000, C428S448000, C428S450000

Reexamination Certificate

active

06995363

ABSTRACT:
A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced in accordance with the present teachings is useful for suppression of matrix ions in the low mass region (<1,000 daltons) of a MALDI-MS spectrum.

REFERENCES:
patent: 5595636 (1997-01-01), Franzen
patent: 5770860 (1998-06-01), Franzen
patent: 6077680 (2000-06-01), Kem et al.
patent: 6265716 (2001-07-01), Hunter et al.
patent: 6287872 (2001-09-01), Schurenberg et al.
patent: 6288390 (2001-09-01), Siuzdak et al.
patent: 6635489 (2003-10-01), Whitney
patent: 6677307 (2004-01-01), Twardzik et al.
patent: 6746775 (2004-06-01), Boire et al.
patent: 6777187 (2004-08-01), Makarov et al.
patent: 6825045 (2004-11-01), Haglund et al.
patent: 6825466 (2004-11-01), Mordekhay
patent: 2002/0051738 (2002-05-01), Schurenberg et al.
patent: 2003/0111600 (2003-06-01), Thomson et al.
patent: 2004/0021071 (2004-02-01), Mordekhay
patent: 2004/0023410 (2004-02-01), Stacey
patent: 2004/0084615 (2004-05-01), Schurenberg
patent: 2004/0229049 (2004-11-01), Boire et al.
patent: 002391066 (2003-07-01), None
patent: WO 02/096541 (2002-05-01), None
Donegan et al., “Controlling matrix suppression for matrix-assisted laser desorption/ionization analysis of small molecules”, Rapid Commun. Mass Spectrom. 2004, vol. 18, pp. 1885-1888.
Vorm et al, “Improved Resolution and Very High Sensitivity in Maldi TOF of Matrix Surfaces Made by Fast Evaporation”, Analytical Chemistry, 1994, vol. 66, No. 19, 3281-3287.
Guo et al, “A Method for the Analysis of Low-Mass Molecules by Maldi-TOF Mass Spectrometry”, Analytical Chemistry, 2002, vol. 74, No. 7, 1637-1641.
Liu et al, “Use of a Nitrocellulose Film Substrate in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry for DNA Mapping and Screening”, Analytical Chemistry, 1995, vol. 67, No. 19, 3482-3490.
Landry et al., “A Method for Application of Samples to Matrix-Assisted Laser Desorption Ionization Time-of-Flight Targets That Enhances Peptide Detection”, Analytical Biochemistry, 279, 1-8 (2000).
Jacobs et al., “Enhancement of the Quality of MALDI Mass Spectra of Highly Acidic Oligosaccharides by Using a Nafion-Coated Probe”, Analytical Chemistry, 2001, vol. 73, No. 3, 405-410.
Miliotis et al, “Ready-made matrix-assisted laser desorption/ionization target plates coated with thin matrix layer for automated sample deposition in high-density array format”, Rapid Communications in Mass Spectrometry, 2002, 16, 117-126.
Sun et al, “Use of nitrocellulose films for affinity-directed mass spectrometry for the analysis of antibody/antigen interactions”, Rapid Communications in Mass Spectrometry, 2001, 15, 1743-1746.
Jonsson et al., “Plasma Desorption Mass Spectrometry of Peptides and Proteins Adsorbed on Nitrocellulose”, Analytical Chemistry, 1986, 58, 1084-1087.

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