Reduction of mammalian neoplasms with phospholipase A2 activatin

Details Reduction of mammalian neoplasms with phospholipase A2 activatin Reduction of mammalian neoplasms with phospholipase A2 activatin

1994-10-13

1996-06-18

Russel, Jeffrey E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 17, 514 21, A61K 3809, A61K 3810, A61K 3816, A61K 3817

Patent

active

055277756

ABSTRACT:
Methods of treating mammalian neoplastic disease are disclosed using phospholipase A.sub.2 activating proteins and fragments thereof.

REFERENCES:
patent: 5122614 (1992-06-01), Zalipsky
patent: 5200176 (1993-04-01), Wong et al.
patent: 5230886 (1993-07-01), Treon et al.
patent: 5294698 (1994-03-01), Bomalski et al.
PNAS, vol. 86, issued Dec. 1989, Beyaert et al, "Lithium chloride potentiates tumor necrosis factor . . .", pp. 9494-9498.
Bomalaski, John S. et al. "Phospholipase A.sub.2 -Activating Protein Induces the Synthesis of IL-1 and TNF in Human Monocytes," J. Immunol. 154:4027-4031, 1995.
Peitsch, Manuel C. et al. "Sequence similarity of phospholipase A.sub.2 activating protein and the G protein .beta.-subunits; a new concept of effector protein activation in signal transductic?", TIBS 18:292-293, 1993.
Bomalaski et al., "A phospholipase A.sub.2 -activating protein (PLAP) stimulates human neutrophil aggregation and release of lysosomal enzymes, superoxide, and eicosanoids", J. of Immunol. 142(11):3957-3962 (Jun. 1, 1989).
Clark et al., "Cloning of phospholipase A.sub.2 -activating protein", Proc. Natl. Acad. Sci. USA 88:5418-5422 (Jun. 1991).
Clark et al., "Leukotriene D.sub.4 treatment of bovine aortic endothelial cells and murine smooth muscle cells in culture results in an increase in phospholipase A.sub.2 activity", Biol. Chem. 261:10713-10718 (Aug. 15, 1986).
Clark et al., "Tumour necrosis factor (cachectin) induces phospholipase A.sub.2 activity and synthesis of a phospholipase A.sub.2 -activating protein in endothelial cells", Biochem. J. 250:250:125-132 (1988).
Imamura et al., "Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D", Biochem. and Biophys. Res. Commun. 193(2):497-503 (Jun. 15, 1993).
Martikainen et al., "Toxic effects of human pancreatic and snake and bee venom phospholipases A.sub.2 on MCF-7 cells in culture", Toxicon 31(7) :835-843 (1993).
Salari et al., "Stimulation of lipoxygenase product synthesis in human leukocytes and platelets by melittin", Mol. Pharm. 28:546-548 (1985).

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