Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1987-09-25
1993-08-03
Stone, Jacqueline
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
604 5, 604 6, 435 2, 435174, 435177, 435178, 435197, 435198, A61K 3754, C12N 1110, C12N 1102, A61M 138
Patent
active
052326969
ABSTRACT:
A method and apparatus for reducing the levels of low density lipoproteins (LDL) in blood is disclosed. The LDL is contacted with an enzyme which modifies it in a manner such that the LDL is rapidly removed endogenously by the patients' own metabolic processes. The enzyme may be introduced into the patient by injection, transdermal transport, nasal insufflation and ingestion. Additionally, the enzyme may be contained in a reactor for both in vivo and extracorporeal use.
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Conlon Hugh D.
Langer, Jr. Robert S.
Lees Robert S.
Mullon Claudy J. P.
Massachusetts Institute of Technology
Stone Jacqueline
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