Reduction of indole compounds to indoline compounds

Details Reduction of indole compounds to indoline compounds Reduction of indole compounds to indoline compounds

1978-01-06

1980-07-01

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260315, 2603269, 562605, 2603473, C07D20904, C07D20994, C07D48704

Patent

active

042105900

ABSTRACT:
A method for reducing indole compounds to the corresponding indoline compounds substantially free of undesirable side reactions is described. The method involves contacting an indole compound with a borane complex reagent in the presence of trifluoroacetic acid. The method is rapidly and readily carried out and provides an excellent method for preparing certain indoline compounds from the corresponding indole compounds. A novel dioxyborane useful as a borane reagent is also disclosed.

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