Reduction of electrostatic forces between magnesium trisilicate

Details Reduction of electrostatic forces between magnesium trisilicate Reduction of electrostatic forces between magnesium trisilicate

1995-01-10

1997-05-06

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424439, 424464, 514770, 514774, 514778, 514781, 514949, 514951, 514961, 514974, A61K 918, A61K 920

Patent

active

056268785

ABSTRACT:
A medicament adsorbate containing corn syrup having contained therein from about 10 to about 90% by weight of the adsorbate of a medicament drug a magnesium trisilicate having a surface area of at least 400 m.sup.2 /g and having a structure with multiple interstitial spaces, and having adsorbed therein from about 0.5 to about 30% by weight of the adsorbate of a medicament drug, wherein the medicament drug is an antihistamine. A reduction in the electrostatic forces between adsorbates is experienced due to the particle size of the adsorbate being in the range greater than 40 to about 800 um, most of the adsorbates prepared being a particle size greater than 150 um, which allows for better processing.

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Prof. Dr.rer.nat.habil. Rudolf Voigt and r.rer.nat. Manfred Borschein (1975). Lehrbuch de pharmazeutischen Technologie. Mit 263 Abbildungen und 111 Tabellen, pp. 157-160.

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