Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1989-06-09
1992-04-28
Moezie, F. T.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530300, 530303, 530324, 530345, 530350, 5303871, 530399, 530402, 530403, 5303911, 435188, C07K 100, C07K 106, C07K 1700, C12N 1100
Patent
active
051091208
ABSTRACT:
The invention provides chemically modified proteins having a group of the formula: ##STR1## wherein R represents a hydrogen atom or a lower alkyl, m represents an optional positive integer and n represents an integer 1 to 4, the group being bonded to at least one primary amino group of the protein, and a method of producing the same. The chemically modified proteins according to the invention can be produced by reacting a protein with an imidoester of the formula: ##STR2## wherein R, n and m are as defined above, R' represents a group constituting an imidoester with an adjacent imidoyl group. The chemically modified proteins according to the invention are useful as drugs, among others.
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Fujino Masahiko
Ueno Hayao
Conlin David G.
Eisenstein Ronald I.
Moezie F. T.
Rozycki Andrew
Takeda Chemical Industries Ltd.
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