Reduction of cell proliferation and enhancement of NK-cell activ

Details Reduction of cell proliferation and enhancement of NK-cell activ Reduction of cell proliferation and enhancement of NK-cell activ

1988-06-30

1992-01-21

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514724, A61K 3145, A61U 3166

Patent

active

050828339

ABSTRACT:
A method for moderating the rate of cellular mitosis in a living mammalian tissue having a pathologically elevated rate of cellular mitosis sensitive to treatment with a solution below which comprises perfusing said tissue under mitotic growth conditions with a safe and effective amount and concentration of a composition consisting essentially of a) inositol hexaphosphate or a physiologically acceptable salt thereof; and b) a source of inositol or a physiologically acceptable salt thereof, for a period of time sufficient to moderate the elevated rate of cellular mitosis to a normal, non-pathological rate for said tissue. The method is useful in human and mammalian diseases wherein NK cell activity is altered in the laboratory, e.g. tumors, other cancers including leukemia, immunosuppressed individuals (AIDS and transplant recipients), and in viral, fungal or protozoal infections.

REFERENCES:
R. B. Heberman et al., J. Natl. Cancer Inst. 62 (3), 441-445 (1979).
R. B. Heberman et al., Science 214, 24-30 (1981).
Dyer, An Index of Tumor Chemotherapy, Wilt, 8/13/51, pp. 10-12, 151 and 152.
Elsayeo et al., Lab Invest, vol. 56, No. 1, 1987, p. 21 A.

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