Reduction of carboxylic esters

Details Reduction of carboxylic esters Reduction of carboxylic esters

1988-04-26

1989-06-27

Reamer, James H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

568648, 568885, C07C 5028

Patent

active

048427756

ABSTRACT:
A method for producing a compound of the formula: ##STR1## [wherein R.sup.1 and R.sup.2 each stand for a lower alkyl group; n denotes an integer of 0 to 21; X stands for hydrogen atom or an optionally protected hydroxyl group; and Y stands for an optionally protected hydroxyl group], which comprises reducing an ester compound of the formula: ##STR2## [wherein R.sup.1, R.sup.2, n, X and Y are of the same meaning as defined above, and R.sup.3 stands for a lower alkyl group ] with a mixture of sodium borohydride and aluminum chloride. This method give the desired compound in a high yield, and is advantageous from the industrial point of view.

REFERENCES:
patent: 4495104 (1985-01-01), Imada et al.
patent: 4559174 (1985-12-01), Okutani et al.
Brown et al., J.A.C.S., vol. 78, pp. 2582-88 (1956).
Fieser et al., Reagents for Organic Synthesis, vol. 2, pp. 347-8.
Fieser et al., Reagents for Organic Synthesis, vol. 1, pp. 940-2.
Fieser et al., Reagents for Organic Synthesis, vol. 1, pp. 1053-4.

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