Reduction in the virulence of Mycobacterium tuberculosis...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

Reexamination Certificate

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C424S009100, C424S009200, C424S184100, C424S234100, C435S440000, C435S471000, C435S477000, C536S023100, C536S023700

Reexamination Certificate

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07468190

ABSTRACT:
The construction of a mutant in the phoP gene by means of homologous recombination from a clinically isolatedMycobacterium tuberculosisreduces the virulence thereof in mouse bone marrow macrophage. Moreover, the phoP mutant reduces the virulence thereof in the experimental mouse model. Said phoP mutant can persist without being eliminated both in the macrophage and in the mouse. Mice inoculated with the phoP mutant are protected againstM. tuberculosisinfection. The use of mutants of mycobacteria in which the phoP gene or the genes regulated by phoP have been inactivated are candidates for vaccines against human and animal tuberculosis as well as possible recombinant vaccines against other pathogens.

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