Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1978-05-25
1981-06-09
Padgett, Benjamin R.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
232303, 422 61, 424 15, 424 9, A61K 4900, A61K 4300
Patent
active
042725038
ABSTRACT:
Reductant compositions for reducing technetium to produce technetium labelled ligands comprise a substrate having attached thereto a reducing complex having sufficient redox potential to reduce technetium from the +7 oxidation state. Preferably the reducing complex comprises a reducing agent for technetium and a chelating ligand therefor. Technetium labelled ligands are prepared by mixing such ligands with pertechnetate in the presence of the reductant of this invention and separating the reductant from the resulting labelled ligand. Technetium labelled ligands that are substantially free from reducing agent used in their preparation may be made in this manner.
REFERENCES:
patent: 3784453 (1974-01-01), Dworkin et al.
Basmadjian et al., "Chemistry of Technitium Phosphate and Phosphonate Complexes: Application to Radio Pharmaceuticals" Private Communication.
Sewatkar, et al., Abstract of Meeting, 15 Internationale Jahrestagung der Gesellschaft fur Nuclearmedizin, 13-16 Sep. 1977.
Basmadjian et al., "Abstract of Meeting 15 Internationale Jahrestagung. der Gesellschaft fur Nuclearmedizin, 13-16 Sep. 1977.
Basmadjian et al., J. Nucl. Med., vol. 18, No. 6, 1977, p. 635.
Camin Leopoldo L.
Liteplo Maria P.
Bronstein Sewall P.
Neuner George W.
New England Nuclear Corporation
Nucker Christine M.
Padgett Benjamin R.
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