Reducing working fluid dilution in liquid systems

Details Reducing working fluid dilution in liquid systems Reducing working fluid dilution in liquid systems

2007-07-24

2007-07-24

Sines, Brian (Department: 1743)

Chemistry: analytical and immunological testing

Automated chemical analysis

With a continuously flowing sample or carrier stream

C422S050000, C422S081000, C422S082000, C422S105000, C422S105000, C436S043000, C436S054000, C436S174000, C436S180000, C137S001000

Reexamination Certificate

active

10464156

ABSTRACT:
A method of transporting a desired fluid in a channel includes: providing a working fluid to transport the desired fluid, such as a sample; providing a first segment of a first buffer fluid which is immiscible with the working fluid and the desired fluid; providing a first segment of the desired fluid; providing a second segment of a second buffer fluid which is immiscible with the working fluid and the desired fluid; providing the desired fluid to be transported and further manipulated; and transporting the desired fluid in the channel by applying a motive force to the working fluid which in turn exerts force against the desired fluid through the first and second buffer fluid. The method prevents dilution of a sample in an apparatus such as a diagnostic analyzer or an apparatus for immunohematological testing of blood. A microfluidics handling system includes a microsystem platform that has: a substrate having: a first flat, planar surface; and a second flat planar surface opposite to the first surface. The first surface includes: at least one microchannel; an optional reagent source; an optional reaction chamber; a source of motive force to transport the fluid; a working fluid in the microchannels; a first segment of a first buffer fluid which is immiscible with the working fluid and the desired fluid; a first segment of the desired fluid; a second segment of a second buffer fluid which is immiscible with the working fluid and the desired fluid; and the desired fluid to be transported and further manipulated, wherein the fluid is present in the microchannels in the order of working fluid; first buffer fluid; first segment of the desired fluid, second buffer fluid; and the desired fluid.

REFERENCES:
patent: 2797149 (1957-06-01), Skeggs
patent: 2879141 (1959-03-01), Skeggs
patent: 3479141 (1969-11-01), Smythe et al.
patent: 3991055 (1976-11-01), Godin et al.
patent: 3992158 (1976-11-01), Przybylowicz et al.
patent: 4121466 (1978-10-01), Reichler et al.
patent: 4259291 (1981-03-01), Smythe
patent: 4526754 (1985-07-01), Burns et al.
patent: 4574850 (1986-03-01), Davis
patent: 4853336 (1989-08-01), Saros et al.
patent: 4984475 (1991-01-01), Uffenheimer et al.
patent: 5399497 (1995-03-01), Kumar et al.
patent: 5441895 (1995-08-01), Jakubowicz et al.
patent: 5552064 (1996-09-01), Chachowski et al.
patent: 5650068 (1997-07-01), Chachowski et al.
patent: 5739036 (1998-04-01), Parris
patent: 5992820 (1999-11-01), Fare et al.
patent: 6096561 (2000-08-01), Tayi
patent: 6453928 (2002-09-01), Kaplan et al.
patent: 6872571 (2005-03-01), Adolfsen et al.
patent: 7077152 (2006-07-01), Karp
patent: WO 88/04052 (1988-06-01), None
patent: WO 97/21090 (1997-06-01), None
patent: WO 02/18949 (2002-03-01), None
U.S. Appl. No. 09/482,599, filed Jan. 13, 2000, Bower et al.

Affiliated with

Also associated with

Rating

Reducing working fluid dilution in liquid systems does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Reducing working fluid dilution in liquid systems, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reducing working fluid dilution in liquid systems will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3748417