Reducing toxicity of L-nucleosides with D-nucleosides

Details Reducing toxicity of L-nucleosides with D-nucleosides Reducing toxicity of L-nucleosides with D-nucleosides

1995-03-16

1999-02-09

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

45 49, 45 50, A61K 3170, C07H 1906, C07H 1916

Patent

active

058694617

ABSTRACT:
The present invention relates to novel methods for reducing toxicity associated with the administration of conventional "D" nucleoside compounds, including anti-HIV nucleosides and related therapeutic agents. Therapeutic methods which rely on conventional "D" nucleosides exhibit unexpectedly reduced toxicity when the methods include the co-administration of effective amounts of "L" nucleoside compounds. The method are particularly useful for the treatment of HIV infections and AIDS related symptoms in humans.

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