Reducing tissue immunogenicity by induction of apoptosis

Details Reducing tissue immunogenicity by induction of apoptosis Reducing tissue immunogenicity by induction of apoptosis

1995-03-24

1999-07-13

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

435 11, 435 12, 424 937, 4242781, A61K 4500

Patent

active

059225980

ABSTRACT:
A cell is subjected to apoptosis, a genetically programmed autolysis of the cell. Cells of a specific type, classified by function, maturity, source, etc. can be effectively removed from a mixture of cells in a tissue or cell suspension by their different sensitivities to the pressure-time treatment. Donor tissue immunogenicity is eliminated by induction of apoptosis in immunoactive cells, such as antigen presenting cells in the donor tissue. When tissues, for example, blood products containing leukocytes or solid tissues containing dendritic cells, are pressure treated to induce apoptosis in the leukocyte or dendritic cell population, the leukocytes or dendritic cells lose their immunoactivity. Viral particles within the target cells, such as cytomegalovirus particles within the apoptosing leukocytes, are destroyed. Apoptosis can be induced, for example, by subjecting a material containing the target cells to a high pressure.

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