Reducing the immunogenicity of fusion proteins

Details Reducing the immunogenicity of fusion proteins Reducing the immunogenicity of fusion proteins

2005-09-23

2009-10-13

Szperka, Michael (Department: 1644)

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

C424S134100, C424S178100, C424S185100, C424S192100, C530S350000, C530S388100

Reexamination Certificate

active

07601814

ABSTRACT:
Disclosed are compositions and methods for producing fusion proteins with reduced immunogenicity. Fusion proteins of the invention include a junction region having an amino acid change that reduces the ability of a junctional epitope to bind to MHC Class II, thereby reducing its interaction with a T-cell receptor. Methods of the invention involve analyzing, changing, or modifying one or more amino acids in the junction region of a fusion protein in order to identify a T-cell epitope and reduce its ability to interact with a T cell receptor. Compositions and methods of the invention are useful in therapy.

REFERENCES:
patent: 4196265 (1980-04-01), Koprowski et al.
patent: 4469797 (1984-09-01), Albarella
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4667016 (1987-05-01), Lai et al.
patent: 4676980 (1987-06-01), Segal et al.
patent: 4703008 (1987-10-01), Lin
patent: 4732683 (1988-03-01), Georgiades et al.
patent: 4737462 (1988-04-01), Mark et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4946778 (1990-08-01), Ladner et al.
patent: 4975369 (1990-12-01), Beavers et al.
patent: 5019368 (1991-05-01), Epstein et al.
patent: 5073627 (1991-12-01), Curtis et al.
patent: 5082658 (1992-01-01), Palladino
patent: 5091513 (1992-02-01), Huston et al.
patent: 5114711 (1992-05-01), Bell et al.
patent: 5116964 (1992-05-01), Capon et al.
patent: 5199942 (1993-04-01), Gillis
patent: 5225538 (1993-07-01), Capon et al.
patent: 5225539 (1993-07-01), Winter
patent: 5258498 (1993-11-01), Huston et al.
patent: 5314995 (1994-05-01), Fell, Jr. et al.
patent: 5349053 (1994-09-01), Landolfi
patent: 5359035 (1994-10-01), Habermann
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5428130 (1995-06-01), Capon et al.
patent: 5441868 (1995-08-01), Lin
patent: 5457038 (1995-10-01), Trinchieri et al.
patent: 5480981 (1996-01-01), Goodwin et al.
patent: 5514582 (1996-05-01), Capon et al.
patent: 5538866 (1996-07-01), Israeli et al.
patent: 5541087 (1996-07-01), Lo et al.
patent: 5543297 (1996-08-01), Cromlish et al.
patent: 5547933 (1996-08-01), Lin
patent: 5552524 (1996-09-01), Basinski et al.
patent: 5585089 (1996-12-01), Queen et al.
patent: 5589466 (1996-12-01), Felgner et al.
patent: 5601819 (1997-02-01), Wong et al.
patent: 5609846 (1997-03-01), Goldenberg
patent: 5614184 (1997-03-01), Sytkowski et al.
patent: 5618698 (1997-04-01), Lin
patent: 5624821 (1997-04-01), Winter et al.
patent: 5639725 (1997-06-01), O'Reilly et al.
patent: 5645835 (1997-07-01), Fell, Jr. et al.
patent: 5650150 (1997-07-01), Gillies
patent: 5650492 (1997-07-01), Gately et al.
patent: 5667776 (1997-09-01), Zimmerman et al.
patent: 5679543 (1997-10-01), Lawlis
patent: 5688679 (1997-11-01), Powell
patent: 5691309 (1997-11-01), Basinski et al.
patent: 5709859 (1998-01-01), Aruffo et al.
patent: 5712120 (1998-01-01), Rodriguez et al.
patent: 5719266 (1998-02-01), DiMarchi et al.
patent: 5723125 (1998-03-01), Chang et al.
patent: 5726044 (1998-03-01), Lo et al.
patent: 5728552 (1998-03-01), Fujisawa et al.
patent: 5733876 (1998-03-01), O'Reilly et al.
patent: 5738852 (1998-04-01), Robinson et al.
patent: 5756349 (1998-05-01), Lin
patent: 5756461 (1998-05-01), Stephens
patent: 5759551 (1998-06-01), Ladd et al.
patent: 5770195 (1998-06-01), Hudziak et al.
patent: 5795779 (1998-08-01), McCormick
patent: 5800810 (1998-09-01), Doyle et al.
patent: 5807715 (1998-09-01), Morrison et al.
patent: 5827516 (1998-10-01), Urban et al.
patent: 5827703 (1998-10-01), Debs et al.
patent: 5837682 (1998-11-01), Folkman et al.
patent: 5837821 (1998-11-01), Wu et al.
patent: 5843423 (1998-12-01), Lyman et al.
patent: 5854205 (1998-12-01), O'Reilly et al.
patent: 5856298 (1999-01-01), Strickland
patent: 5858347 (1999-01-01), Bauer et al.
patent: 5885795 (1999-03-01), O'Reilly et al.
patent: 5886178 (1999-03-01), Allen et al.
patent: 5888772 (1999-03-01), Okasinski et al.
patent: 5888773 (1999-03-01), Jost et al.
patent: 5891680 (1999-04-01), Lieschke et al.
patent: 5908626 (1999-06-01), Chang et al.
patent: 5922685 (1999-07-01), Rakhmilevich et al.
patent: 5955422 (1999-09-01), Lin
patent: 5994104 (1999-11-01), Anderson et al.
patent: 5994126 (1999-11-01), Steinman et al.
patent: 6080409 (2000-06-01), Laus et al.
patent: 6086875 (2000-07-01), Blumberg et al.
patent: 6100387 (2000-08-01), Herrmann et al.
patent: 6169070 (2001-01-01), Chen et al.
patent: 6171588 (2001-01-01), Carron et al.
patent: 6231536 (2001-05-01), Lentz
patent: 6277375 (2001-08-01), Ward
patent: 6281010 (2001-08-01), Gao et al.
patent: 6284536 (2001-09-01), Morrison et al.
patent: 6291158 (2001-09-01), Winter et al.
patent: 6335176 (2002-01-01), Inglese et al.
patent: 6340742 (2002-01-01), Burg et al.
patent: 6348192 (2002-02-01), Chan et al.
patent: 6406689 (2002-06-01), Falkenberg et al.
patent: 6429199 (2002-08-01), Krieg et al.
patent: 6444792 (2002-09-01), Gray et al.
patent: 6475717 (2002-11-01), Enssle et al.
patent: 6485726 (2002-11-01), Blumberg et al.
patent: 6500641 (2002-12-01), Chen et al.
patent: 6506405 (2003-01-01), Desai et al.
patent: 6551592 (2003-04-01), Lindhofer et al.
patent: 6583272 (2003-06-01), Bailon
patent: 6586398 (2003-07-01), Kinstler et al.
patent: 6617135 (2003-09-01), Gillies et al.
patent: 6627615 (2003-09-01), Debs et al.
patent: 6646113 (2003-11-01), Dreyfuss et al.
patent: 6838260 (2005-01-01), Gillies et al.
patent: 6946134 (2005-09-01), Rosen et al.
patent: 6969517 (2005-11-01), Gillies et al.
patent: 6992174 (2006-01-01), Gillies et al.
patent: 7067110 (2006-06-01), Gillies et al.
patent: 7091321 (2006-08-01), Gillies et al.
patent: 7141651 (2006-11-01), Gillies et al.
patent: 7148321 (2006-12-01), Gillies et al.
patent: 7169904 (2007-01-01), Gillies et al.
patent: 7186804 (2007-03-01), Gillies et al.
patent: 7211253 (2007-05-01), Way
patent: 7226998 (2007-06-01), Gillies et al.
patent: 7323549 (2008-01-01), Lauder et al.
patent: 7465447 (2008-12-01), Gillies et al.
patent: 2001/0053539 (2001-12-01), Lauffer et al.
patent: 2002/0037558 (2002-03-01), Lo et al.
patent: 2002/0081664 (2002-06-01), Lo et al.
patent: 2002/0142374 (2002-10-01), Gallo et al.
patent: 2002/0146388 (2002-10-01), Gillies
patent: 2002/0147311 (2002-10-01), Gillies et al.
patent: 2002/0192222 (2002-12-01), Blumberg et al.
patent: 2002/0193570 (2002-12-01), Gillies et al.
patent: 2003/0003529 (2003-01-01), Bayer
patent: 2003/0012789 (2003-01-01), Blumberg et al.
patent: 2003/0044423 (2003-03-01), Gillies et al.
patent: 2003/0049227 (2003-03-01), Gillies et al.
patent: 2003/0105294 (2003-06-01), Gillies et al.
patent: 2003/0139365 (2003-07-01), Lo et al.
patent: 2003/0139575 (2003-07-01), Gillies
patent: 2003/0157054 (2003-08-01), Gillies et al.
patent: 2003/0166163 (2003-09-01), Gillies
patent: 2003/0166877 (2003-09-01), Gillies et al.
patent: 2004/0013640 (2004-01-01), Zardi et al.
patent: 2004/0033210 (2004-02-01), Gillies
patent: 2004/0043457 (2004-03-01), Schumacher et al.
patent: 2004/0053366 (2004-03-01), Lo et al.
patent: 2004/0072299 (2004-04-01), Gillies et al.
patent: 2004/0082039 (2004-04-01), Gillies et al.
patent: 2004/0180035 (2004-09-01), Gillies
patent: 2004/0180386 (2004-09-01), Carr et al.
patent: 2004/0203100 (2004-10-01), Gillies et al.
patent: 2005/0042729 (2005-02-01), Lo et al.
patent: 2005/0069521 (2005-03-01), Gillies et al.
patent: 2005/0137384 (2005-06-01), Gillies et al.
patent: 2005/0164352 (2005-07-01), Lauder et al.
patent: 2005/0192211 (2005-09-01), Gillies et al.
patent: 2005/0202021 (2005-09-01), Gillies
patent: 2005/0202538 (2005-09-01), Gillies et al.
patent: 2005/0244418 (2005-11-01), Gillies et al.
patent: 2005/0261229 (2005-11-01), Gillies et al.
patent: 2006/0034836 (2006-02-01), Gillies et al.
patent: 2006/0141581 (2006-06-01), Gillies et al.
patent: 2006/0194952 (2006-08-01), Gillies et al.
patent: 2006/0228332 (2006-10-01), Gillies et al.
patent: 2006/0263856 (2006-11-01), Gillies et al.
patent: 2007/0036752 (2007-02-01), Gillies et al.
patent: 2007/0059282 (2007-03-01), Gillies et al.
patent: 2007/0104689 (2007-05-01), Gillies et al.
patent: 2007/0154453 (2007-07-01), Webster et al.
patent: 2007/0154473 (2007-07-01), S

Affiliated with

Also associated with

Rating

Reducing the immunogenicity of fusion proteins does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Reducing the immunogenicity of fusion proteins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reducing the immunogenicity of fusion proteins will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4077703