Reducing post-prandial fluctuations in plasma concentrations of

Details Reducing post-prandial fluctuations in plasma concentrations of Reducing post-prandial fluctuations in plasma concentrations of

1989-04-03

1993-04-27

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, 514 21, 548496, C07D 3702, A23J 304, A23J 308

Patent

active

052062180

ABSTRACT:
Methods of reducing post-prandial fluctuations in plasma levels of large, neutral amino acids (LNAA), as well as compositions useful in that method. The foods and compositions comprise a carbohydrate to protein ratio of from about 3:1 to about 6:1 and, in a specific embodiment, a ratio of 4:1, which results in minimizing the variability in responses individuals exhibit to drugs which are LNAA.

REFERENCES:
Fernstrom J. D. and Wurtman R. J. "Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids." Science 178: 414-416 (1972).
Fernstrom J. D. and Faller D. V. "Neutral Amino Acids in the Brain: Changes in Response to Food Ingestion." Journal of Neurochemistry 30: 1531-8 (1978).
Yokogoshi H. and Wurtman R. J. "Meal Composition and Plasma Amino Acid Ratios: Effect of Various Proteins or Carbohydrates, and of Various Protein Concentrations." Metabolism 35/9: 837-842 (1986).
Juncos J. L., Fabbrini G., Mouradian M. M., Serrati C, and Chase T. N. "Dietary Influences on the Antiparkinsonian Response to Levodopa." Arch Neurol 44: 1003-5 (1987).
N. G. Gillespie et al., J. Am. Dietetic Assoc., 62(S): 525-528 (1973).
D. Markovitz et al., Proc. Fed. Am. Soc. Exp. Biol. 36(3): Abstr. 609 (1977).
Fernstrom et al., Amer. J. Clin. Nutrition, 32: 1912-1922 (1979).
Markovitz and Fernstrom, Science, 179: 1014-1015 (1977).
Cotzias et al., Adv. in Neurol., 2: 265-277 (1973).
Wurtman and Caballero, New Eng. J. Med., 319: 1288-1289 (1988).

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