Reducing NgR-p75 mediated inhibition of axon regeneration

Details Reducing NgR-p75 mediated inhibition of axon regeneration Reducing NgR-p75 mediated inhibition of axon regeneration

2005-12-27

2009-12-01

Kemmerer, Elizabeth C. (Department: 1649)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007100

Reexamination Certificate

active

07625709

ABSTRACT:
Inhibitors of Nogo Receptor (NgR)-p75 binding are used to reduce NgR-p75 binding mediated axon growth inhibition. Mixtures of NgR and p75 are used in pharmaceutical screens to characterize agents as inhibiting binding of NgR to p75 and promoting axon regeneration.

REFERENCES:
patent: WO03031462 (2001-10-01), None
Wang et al (2002). Nature. 420, 74-78.
Laduga et al (1997). Protein engineering. 10, 187-196.

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