Reducing muscle fatigue

Details Reducing muscle fatigue Reducing muscle fatigue

1998-11-25

2000-11-07

Cook, Rebecca

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514557, A61K 3122

Patent

active

061437840

ABSTRACT:
A method of reducing muscle fatigue during exercise or for treating chronic heart failure, the method comprising increasing the concentration of TCA cycle intermediates in the muscle mitochondria by the administration of pyruvate to the body.

REFERENCES:
Metabolic responses from rest to steady state determine contracile function in ischemic skeletal muscle, Jack A. Timmons, et al., American Physiological Society, pp. E233-238, 1997.
Maximum Rate of Oxygen uptake by humas skeletal muscle in relation to maximal activities of enzymers in the Krebs Cycle, Eva Blomstrand et al., Journal of Physiology (1997) pp. 455-460.
Tricarboxylic acid cycle intermediates in human muscle during prolonged exercise, K Sahlin et al., The American Physiological Society, 1990, pp. C835-C841.

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