Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Insulin; related peptides
Patent
1995-06-07
1997-05-20
Russel, Jeffrey E.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Insulin; related peptides
530305, 530344, 530345, 530410, 530417, C07K 1113, C07K 116, C07K 134, C07K 1462
Patent
active
056313470
ABSTRACT:
A method for processing a fatty acid-acylated protein, especially N-palmitoyl Lys.sup.B29 human insulin, to reduce the incidence of gelation by conducting such processing in the presence of a citrate buffering agent as the primary buffer which method allows such processing to be conducted at higher protein concentrations and with less temperature control than would otherwise be possible in the absence of the citrate buffer.
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Baker Jeffrey C.
Hanquier Jose M.
Shrader Warren E.
Boone David E.
Caltrider Steven P.
Carroll Kathleen
Eli Lilly and Company
Russel Jeffrey E.
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