Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2008-07-29
2008-07-29
Bertoglio, Valarie (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S325000, C435S366000, C435S368000
Reexamination Certificate
active
10687677
ABSTRACT:
A synthetic, nuclear-encoded ND4 gene was linked to a mitochondrial targeting sequence and a FLAG epitope tag. This fusion construct was inserted into a rAAV vector. The ND4 fusion protein was expressed and imported into the mitochondria of cells harboring a mitochondrial DNA mutation (G11778A), where it restored cellular respiration.
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Akerman & Senterfitt
Bertoglio Valarie
Dobbelaere Amy A.
Nelson Gregory A.
Shen Wu-Cheng Winston
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