Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1984-02-22
1987-05-26
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 14, 435184, 435810, 436801, 436825, G01N 33535
Patent
active
046686207
ABSTRACT:
Background interference which disrupts the measurement of an analyte in enzyme immunoassays with samples is substantially diminished. In accordance with one embodiment of the invention, the serum sample is treated with a sufficient amount of a peracid compound, either organic or inorganic, for a time and under conditions sufficient to reduce or eliminate background interference contributed by serum components other than analyte. The peracid compound is readily quenched, without adversely affecting the assay compositions. In another embodiment of the invention a liqand for the interfering component of the sample, such as unconjugated enzyme which is inactive but antigenic, is mixed with the sample to be analyzed. The presence of the liqand substantially reduces or eliminates background interference from components of the sample other than analyte.
REFERENCES:
patent: 4434227 (1984-02-01), Unger
patent: 4444880 (1984-04-01), Tom
patent: 4455381 (1984-06-01), Magnusson
patent: 4472508 (1984-09-01), Ingbar
patent: 4483922 (1984-11-01), Carpenter
Chemical Abstracts, I, 91:153803t (1979).
Chemical Abstracts, II, 94:152970v (1981).
Armenta Richard
Gibbons Ian
Olson John
Barrett Carole F.
Leitereg Theodore J.
Marantz Sidney
Syntex (U.S.A.) Inc.
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