Reducing agent for reductive alkylation of glycopeptide antibiot

Details Reducing agent for reductive alkylation of glycopeptide antibiot Reducing agent for reductive alkylation of glycopeptide antibiot

1997-11-12

1999-08-17

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, 530322, 530323, 530345, A61K 3812, A61K 3814, C07K 900

Patent

active

059393823

ABSTRACT:
This invention is concerned with improved processes for reductive alkylation of glycopeptide antibiotics, the improvement residing in employing pyridine.borane as reducing agent.

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Stults, N.L., et al., Anal. Biochem., 180, 114-119 (1989).
Bomann, M.D., et al., J. Org. Chem., 60, 5995-5996 (1995).
Pelter, A., et al., J. Chem. Soc., Perkin Trans. 1, 717-720 (1984).
Wong, W.S.D., et al., Anal. Biochem., 139, 58-67 (1984).
Nagabhushan, T.L. et al., Carbohydrate Research, 130, 243-249 (1984).
Nagarajan, R., et al., J. of Antibiotics, XLII, No. 1, 63-72 (Jan. 1989).
Cooper, R.D.G., et al., J. of Antibiotics, 49, No. 6,575-581 (Jun. 1996).
Lee, R.T., et al., Biochemistry, 28, 1856-1861 (1989).

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