Reduced-viscosity concentrated protein formulations

Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,...

Reexamination Certificate

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C424S133100, C424S141100, C424S143100, C424S174100, C424S176100, C424S177100, C514S002600, C530S350000, C530S387100, C530S387300, C530S388100, C530S388220, C530S388850, C530S389700, C530S390100, C530S390500

Reexamination Certificate

active

06875432

ABSTRACT:
The present application concerns concentrated protein formulations with reduced viscosity, which are particularly suitable for subcutaneous administration. The application further concerns a method for reducing the viscosity of concentrated protein formulations.

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White et al, Principles of Biochemistry, 3RD Edition, McGraw-Hill Book Company, p. 540, 1964.*
Presta et al., “Humanization of an Antibody Directed Against IgE”J. Immunol.151 (5) :2623-2632 (Sep. 1, 1993).
Zietkiewicz et al., “In Vivo Studies on the Action on the Tissue of the Osmolality of Parenterally Administered Drugs.”Grzyby Drozdzopodobne.(English Translation Attached) 23:869-870 (1971).
Jones, A., “Analysis of Polypeptides and Proteins.”Adv. Drug Delivery Rev.(10)29-90 (1993).

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