Reduced FK228 and use thereof

Details Reduced FK228 and use thereof Reduced FK228 and use thereof

2006-06-06

2006-06-06

Lambkin, Deborah C. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S317000, C530S323000

Reexamination Certificate

active

07056884

ABSTRACT:
The present invention relates to reduced FK228 of the formula (I)wherein R1and R2are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and a histone deacetylase inhibitor containing this compound, an expression potentiator and a reactivation promoter of a transgene, and pharmaceutical agents containing them as active ingredients. The reduced FK228 or a salt thereof has a strong histone deacetylase inhibitory activity and this compound can be used for the prophylaxis or treatment of various diseases, in which histone deacetylation is involved, and for the gene therapy of such diseases.

REFERENCES:
patent: 4977138 (1990-12-01), Okuhara et al.
patent: 5847074 (1998-12-01), Yamasaki et al.
patent: 352646 (1990-01-01), None
patent: 95/7293 (1995-03-01), None
Khan W. Li et al.: “Total synthesis of the antitumor depsipeptide FR-901,228” J. Am. Chem. Soc., vol. 118, pp. 7237-7238 1996.
U.S. Appl. No. 11/064,292, filed Feb. 24, 2005, Naoe et al.
U.S. Appl. No. 10/333,063, filed Sep. 29, 2003, Nakajima et al.

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