Reduced bioirritant composition

Details Reduced bioirritant composition Reduced bioirritant composition

2005-10-19

2010-06-29

Azpuru, Carlos A (Department: 1615)

Drug, bio-affecting and body treating compositions

Topical body preparation containing solid synthetic organic...

Ophthalmic preparation

Reexamination Certificate

active

07744860

ABSTRACT:
A method for reducing irritancy of ascorbic acid administered to a biological surface for anti-angiogenic, anti-oxidant, anti-inflammatory and other effects. It has been discovered that pH neutralized ascorbic acid retains the efficacy of non-pH neutralized ascorbic acid in reducing neovascularization, providing an anti-oxidant effect, etc. but is less irritating and thus enhances patient comfort and compliance. It may be administered into or on the eye, on skin, into a body cavity, etc. either alone or with other agents.

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Hanashima et al, “reduced Viability of Vascular Endothial Cells by High COncentration of Ascorbic Acid in Vitreous Humor”, Cell Biology International, vol. 23, Issue 4, Apr. 1999, pp. 287-298 (abstract only).
Merriam-Webster Online Dictionary, Definition of “Prophylactic”, 2007.

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