Reduced alcohol mouthwash antiseptic and antiseptic preparation

Details Reduced alcohol mouthwash antiseptic and antiseptic preparation Reduced alcohol mouthwash antiseptic and antiseptic preparation

1997-01-21

1998-03-03

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

424 58, A61K 716, A61K 726

Patent

active

057231060

ABSTRACT:
Reduced alcohol antiseptic mouthwash compositions are achieved which have the same oral antimicrobial efficacy, clarity and taste as higher alcohol level compositions. Availability of the active ingredients is best maintained by increasing the levels of surfactant employed in the composition together with the addition of two co-solvents, propylene glycol and glycerin. Propylene glycol with artificial sweetener(s), or propylene glycol alone with corresponding increases in the levels of surfactant are only marginally acceptable.

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Janistyn, Handbuch der Kosmetika und Riechstoffe, band 3, Die Korperpflegemittel 1973, Huthig, DE see p. 788, example "Mundwasser amerikanische Type".
Advertising Age Mar. 16, 1992 Cool Mint Listerine has Lower Alcohol Content than Original Listerine.
Advertising Age Sep. 25, 1991 p. 70 Listerine 26.9% Alcohol has A.D.A. Seal of Approval It's No. 1 Mouthwash 30% of $8,000,000 U.S. Market.
Advertising Age Apr. 29, 1991 p. 50 ADA Looks at Listerine--26.9% Alcohol.
Federal Register 58 Fr. 54466 vol. 58 No. 202 oct. 21, 1993 Over the Counter Drug Products Intended for Oral Ingestion that Contain Alcohol--Dec. 17, 1992 Meeting of OTC Drugs Advisory Committee.
Federal Register 59 FR 6084 vol. 59 No. 127 Feb. 9, 1994 Oral Healthcare Drug Products for Over-the-Counter Human Use; Tentative Final Monograph for Oral and Septic Products--Dec. 17, 1992 OTC Drugs Advisory Comittee Recommended not More than the Minimum Amount of Alcohol Needed as a Solvent . . . etc.
Federal Register 59 FR 24386 vol. 59 No. 090 May 11, 1994 Proposed Rule: Mouthwash Packages Containing 3 Grams or More of Ethanol.

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