Redispersible nanoparticulate film matrices with protective over

Details Redispersible nanoparticulate film matrices with protective over Redispersible nanoparticulate film matrices with protective over

1995-02-13

1996-11-12

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424484, 424488, 424489, A61K 916, A61K 950

Patent

active

055737838

ABSTRACT:
A pharmaceutical film matrix comprising nanoparticles of a low solubility drug associated with a steric stabilizer and a film dispersing agent is coated on the surface of carrier particles and overcoated with a protective layer. Pharmaceutical compositions comprising the film matrix-coated carrier exhibit excellent bioavailability, are useful in methods of treating mammals and are extremely stable in that they are capable of being redispersed without extensive agglomeration into larger particles after being stored.

REFERENCES:
patent: 4946686 (1990-08-01), McClelland et al.
patent: 5118528 (1992-06-01), Fessi et al.
patent: 5145684 (1992-09-01), Liverside et al.
patent: 5308620 (1994-05-01), Yen
patent: 5399363 (1995-03-01), Liversidge et al.
Lachman et al, "The Theory and Practice of Industrial Pharmacy", Chapter 2, "Milling", p. 45 (1986).
Martindale, "The Extra Pharmacopoeia, 29 edition", (1969).
Lieberman, Rieger, Baker, "Pharmaceutical Dosage Forms: Dispense Systems", vol. 1.

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