Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...
Patent
1995-02-24
1999-06-15
Stanton, Brian R.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
435325, 435366, 435352, 435354, C12N 510
Patent
active
059121700
ABSTRACT:
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.
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Grynk
Kolanus Waldemar
Romeo Charles
Seed Brian
Hauda Karen M.
Stanton Brian R.
The General Hospital Corporation
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