Redirection of cellular immunity by protein tyrosine kinase...

Details Redirection of cellular immunity by protein tyrosine kinase... Redirection of cellular immunity by protein tyrosine kinase...

2008-01-22

2008-01-22

Wehbe, Anne M. (Department: 1633)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

C424S093200, C424S093100, C435S325000, C435S366000, C435S372300, C435S455000, C435S320100

Reexamination Certificate

active

07320787

ABSTRACT:
Disclosed is a method of directing a cellular response in a mammal by expressing in a cell of the mammal a chimeric receptor which causes the cells to specifically recognize and destroy an infective agent, a cell infected with an infective agent, a tumor or cancerous cell, or an autoimmune-generated cell. The chimeric receptor includes an extracellular portion which is capable of specifically recognizing and binding the target cell or target infective agent, and (b) an intracellular portion of a protein-tyrosine kinase which is capable of signalling the therapeutic cell to destroy a receptor-bound target cell or a receptor-bound target infective agent. Also disclosed are cells which express the chimeric receptors and DNA encoding the chimeric receptors.

REFERENCES:
patent: 4690915 (1987-09-01), Rosenberg
patent: 4946778 (1990-08-01), Ladner et al.
patent: 5091513 (1992-02-01), Huston et al.
patent: 5225538 (1993-07-01), Capon et al.
patent: 5336603 (1994-08-01), Capon et al.
patent: 5359046 (1994-10-01), Capon et al.
patent: 5439819 (1995-08-01), Littman et al.
patent: 5504000 (1996-04-01), Littman et al.
patent: 5686281 (1997-11-01), Roberts
patent: 5712149 (1998-01-01), Roberts
patent: 6284240 (2001-09-01), Seed et al.
patent: 6410014 (2002-06-01), Seed et al.
patent: 0 180 878 (1986-05-01), None
patent: 0 314 317 (1989-05-01), None
patent: 0 325 262 (1989-07-01), None
patent: 0 340 793 (1989-11-01), None
patent: 0 394 827 (1990-10-01), None
patent: 10-63394 (1989-03-01), None
patent: 224379 (1990-12-01), None
patent: WO 86/01533 (1986-03-01), None
patent: WO 88/01649 (1988-03-01), None
patent: WO 90/04640 (1990-05-01), None
patent: WO 90/11360 (1990-10-01), None
patent: WO 91/10736 (1991-07-01), None
patent: WO 92/10591 (1992-06-01), None
patent: WO 92/15322 (1992-09-01), None
patent: WO 93/19163 (1993-09-01), None
patent: WO 95/02686 (1995-01-01), None
patent: WO 95/21528 (1995-08-01), None
patent: WO 96/26265 (1996-08-01), None
Johnston et al. (1993) Science, vol. 260, 1286-1293.
Hoffenbach et al. (1989) J. Immunol., vol. 142(2), 452-462.
Fox (1994) Bio/Technology, vol. 12, 128.
Yamada et al. (1993) Eur. J. Biochem., vol. 213, 455-459.
Chen et al. (1998) Virology, vol. 246, 113-124.
LaBronte et al. (2002) J. Exp. Med., vol. 196(4) 431-445.
Abraham and Veillette, Mol. Cell. Biol. 10:5197-5206, 1990.
Accolla, J. Exp. Med., 157:1053-1058, 1983.
Al-Jaufy et al., Infection and Immunity, 62:956-960, 1994.
Alberola-Ila et al., J. Immunology 151(9):4423-4430, (Nov. 1, 1993).
Anderson et al., “CD3-negative Natural Killer Cells Express TCR as Part of a Novel Molecular Complex,” Nature 341:159-162, 1989.
Anderson et al., “Fc Receptor Type III (CD16) is Included in the NK Receptor Complex Expressed by Human Natural Killer Cells,” Proc. Natl. Acad. Sci. USA 87: 2274-2278, 1990.
Appleby et al., Cell 70:751-763, 1992.
Aruffo and Seed, EMBO J. 6:3313, 1987.
Aruffo et al., “Molecular Cloning of a CD28 cDNA by a High-Efficiency COS Cell Expression System,” Proc. Natl. Acad. Sci. USA 84: 8573-8577, 1987.
Ashom et al., J. Virol. 64:2149 1990.
Aullo et al., EMBO J. 11:575-583, 1992.
Bachmann et al. “In vivo versus in vitro assays for assessment of T-and B-cell function” Current Opinion in Immunology, vol. 8 (2), 320-328, 1994.
Balk and Terhorst, Immunol. Ser. 45:411-416, 1989.
Baniyash et al., J. Biol. Chem. 263:9874-9878, 1988.
Bauer et al., Proc. Natl. Acad. Sci. USA 88:3842-3846, 1991.
Becker et al., “Expression of a Hybrid Immunoglobulin-T Cell Receptor Protein in Transgenic Mice,” Cell 58: 911-921, 1989.
Becker et al., “Messenger RNA in Cells Infected with Vaccinia Virus,” Biochemistry 51: 577-585, 1964.
Bell et al., Mol. Cell. Biol. 12:5548-5554, 1992.
Berke et al., “T Lymphocyte-Mediated Cytolysis—A Comprehensive Theory,” Mechanisms of Cell Mediated Cytotoxicity, 57-68, 1982.
Berke, “Lymphocyte-Triggered Internal Target Disintegration,” Immunology Today 12:396-399, 1991.
Berke, “Cytotoxic T-Lymphocytes; How Do They Function?,” Immunological Rev. 72:5-42, 1983.
Berkhout et al., “Transfection of Genes Encoding the T Cell Receptor-Associated CD3 complex into COS Cells Results in Assembly of the Macromolecular Structure.” Journal of Biological Chemsitry 263:8528-8536, 1988.
Blank et al., “Complete Structure and Expression in Transfected Cells of High Affinity IgE Receptor,” Nature 337:187-189, 1989.
Blumberg et al., “Antibody-Dependent Cell-Mediated Cytotoxicity Against Cells Infected with the Human immunodeficiency Virus.” Journal of Infectious Diseases 156:878-883, 1987.
Blumberg et al., J. Biol. Chem. 265:14036, 1990.
Bolen et al., Adv. Cancer Res. 57:103-149, 1991.
Boyle et al., “A Dominant Selectable Marker for the Construction of Recombinant Poxviruses,” Gene 65:123-128, 1988.
Breitmeyer et al., J. Immunol. 138:726, 1987.
Brown, Washngton Post, A1 and A22 (Dec. 8, 1995).
Buonocore et al., “Prevention of HIV-1 glycoprotein Transport by Soluble CD4 Retained in the Endoplasmic Reticulum,” Nature 345:625-628, 1990.
Burkhardt et al., Proc. Natl. Acad. Sci. USA 88:7410-7414, 1991.
Clark et al., Science 258:123-126, 1992.
Clark and Ledbetter, Adv. Cancer Res. 52:81-149, 1989.
Clayton et al., Proc. Natl. Acad. Sci. USA 88:5202-5206, 1991.
Clayton et al., “Characterization of Thymus-Derived Lymphocytes Expressing Antigen Receptor Isoforms: Analysis by Gene Transfection,” J. Exp. Med. 172:1243-1253, 1990.
Cline, “Gene Therapy: Current Status and Future Directions,” Schweiz, Med. Wschr. 116:1459-1464, 1986.
Coghlan et al., New Scientist 14-15 (Nov. 25, 1995).
Cooke and Perlmutter, New Biol. 1:66-74, 1989.
Cooke et al., Cell 65:281-291, 1991.
Dalgleish et al., “The CD4(T4) Antigen is an Essential Component of the Receptor for the AIDS Retrovirus,” Nature 312:763-767, 1984.
Davidson et al., J. Exp. Med. 175:1483-1492, 1992.
Deen et al., “A Soluble Form of CD4(T4) Protein Inhibits AIDS Virus Infection,” Nature 331: 82-84, 1988.
DeFranco, Eur. J. Biochem. 210:381-388, 1992.
Denny et al., “A Chromosome 14 Inversion in a T-Cell Lymphoma is Caused by Site-Specific Recombination Between Immunoglobulin and T-Cell Receptor Loci,” Nature 320:549-551, 1986.
Doyle et al., “Interaction Between CD4 and Class II MHC Molecules Mediates Cell Adhesion,” Nature 330: 256-259, 1987.
Earl et al., “Removal of Cryptic Poxvirus Transcription Termination Signals from the Human Immunodeficiency Virus Type 1 Envelope Gene Enhances . . . ,” Journal of Virology, 64:2448-2451, 1990.
Eiseman and Bolen, Nature 355:78-80, 1992.
Falkner et al., “Escherichia coligpt Gene Provides Dominant Selection for Vaccinia Virus Open Reading Frame Expression Vectors,” Journal of Virology, 62:1849-1854, 1988.
Fanger et al., “Cytotoxicity Mediated by Human Fc Receptors for IgG,” Immunology Today 10: 92-99, 1989.
Fisher et al., “HIV Infection is Blocked in Vitro by Recombinant Soluble CD4,” Nature 331:76-78, 1988.
Fleit et al., Proc. Natl. Acad. Sci. USA 79:3275-3279, 1982.
Frank et al., “Structural Mutations of the T Cell Receptor Chain and Its Role in T Cell Activation,” Science 249: 174-177, 1990.
Friedman et al., “Expression of a Truncated Viral Trans-activator Selectively Impedes Lytic Infection by its Cognate Virus,” Nature 335:452-454, 1988
Gassmann et al., Eur. J. Immunol. 22:283-286, 1992.
Gay et al., “Functional Interaction Between Human T-Cell Protein CD4 and the Major Histocompatibility Complex HLA-DR Antigen,” Nature 328: 626-629, 1987.
Glaichenhaus et al., Cell 64:511-520, 1991.
Gold et al., Nature 345:810-813, 1990.
Goldsmith and Weiss, Proc. Natl. Acad. Sci. USA 84:6879-6883, 1987.
Golstein et al., Immunol. Rev. 68:5-42, 1982.
Gorny et al., Proc. Natl. Acad. Sci. USA 86: 1624,1989.
Goverman et al., “Chimeric Immunoglobulin-T Cell Receptor Prote

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