Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2008-07-01
2008-07-01
Sullivan, Daniel M. (Department: 1636)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C536S023100, C435S320100, C435S325000
Reexamination Certificate
active
10984694
ABSTRACT:
Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising such vectors.
REFERENCES:
patent: 5625048 (1997-04-01), Tsien et al.
patent: 6723537 (2004-04-01), Peele
patent: WO 00/34318 (2000-06-01), None
patent: WO 00/34318 (2002-06-01), None
patent: WO 03/045304 (2003-06-01), None
Bachl et al. Hypermutation targets a green fluorescent protein-encoding trangene in the presence of immunoglobulin enhancers. Eur. J. Immunol. vol. 29, pp. 1383-1389, 1999.
Matz, M. V., et al. “Fluorescent Proteins Form NonBioluminescent Anthozoa Species”, Nature Biotechnology, vol. 17, No. 10, pp. 969-973, Oct. 1999.
Ormö, Mats, et al., “Crystal Structure of theAequorea victoriaGreen Fluorescent Protein”, Science, vol. 273, pp. 1392-1395, Sep. 6, 1996.
Yanushevich, Yurii G., et al., “A Strategy for the Generation of Non-Aggregating Mutants ofAnthozoaFluorescent Proteins”, FEBS Letters 511, pp. 11-14, 2002.
Bachl et al., “Increased Transcription Levels Induce Higher Mutation Rates in a Hypermutating Cell Line”, The Journal of Immunology, vol. 166, pp. 5051-5057, 2001.
Campbell et al., “A monomeric red fluorescent protein”, PNAS, vol. 99, No. 12, pp. 7877-7882, Jun. 11, 2002.
Gearhart, Patricia J., “The roots of antibody diversity”, Nature, vol. 419, pp. 29-31, Sep. 5, 2002.
Goff, Stephen P., “Death by Deamination: A Novel Host Restriction System for HIV-1”, Cell Press, vol. 114, pp. 281-283, Aug. 8, 2003.
Harris et al., “RNA Editing Enzyme APOBEC1 and Some of Its Homologs Can Act as DNA Mutators”, Molecular Cell, vol. 10, pp. 1247-1253, Nov. 2002.
Landis et al., “High-Frequency Generation of Conditional Mutations AffectingDrosophila melanogasterDevelopment and Life Span”, Genetics, vol. 158, pp. 1167-1176, Apr. 25, 2001.
Li et al., “The generation of antibody diversity through somatic hypermutation and class switch recombination”, Genes & Development, vol. 18, pp. 1-11, 2004.
Martin et al., “Somatic hypermutation of the AID transgene in B and non-B cells”, PNAS, vol. 99, No. 19, pp. 12304-12308, Jul. 25, 2002.
Martin et al., “Activation-induced cytidine deaminase turns on somatic hypermutation in hybridomas”, Nature, vol. 415, pp. 802-805, Feb. 14, 2002.
Pasqualucci et al., “Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas”, Nature, vol. 412, pp. 341-346, Jul. 19, 2001.
Petersen-Mahrt et al., “AID mutatesE. colisuggesting a DNA deamination mechanism for antibody diversification”, Nature, vol. 418, pp. 99-103, Jul. 4, 2002.
Rajewsky et al., “Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse”, Science, vol. 238, pp. 1088-1094, Nov. 20, 1987.
Sale et al., “TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line”, Immunity, vol. 9, pp. 859-869, Dec. 1998.
Sale et al., “Ablation of XRCC2/3 transforms immunoglobulin V gene conversion into somatic hypermutation”, Nature, vol. 412, pp. 921-026, Aug. 30, 2001.
Shaner et al., “Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein”, Nature Biotechnology, vol. 10, pp. 1-6, Nov. 21, 2004.
Shagin et al., “GFP-like Proteins as Ubiquitous Metazoan Superfamily: Evolution of Functional Features and Structural Complexity”, Molecular Biology and Evolution, vol. 21, No. 5, pp. 841-850, 2004.
Shen et al., “The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and BCL6 genes are hypermutated in human memory B cells”, International Immunology, vol. 12, No. 7, pp. 1085-1093, Mar. 31, 2000.
Storb et al., “Somatic hypermutation of immunoglobulin and non-immunoglobulin genes”, Phil. Trans. R. Soc. Lond., vol. 356, pp. 13-19, 2001.
Wang et al., “Genome-wide somatic hypermutation”, PNAS, vol. 101, No. 19, pp. 7352-7356, May 11, 2004.
Wang et al., “Evolution of new nonantibody proteins via iterative somatic hypermutation”, PNAS, vol. 101, No. 19, pp. 7352-7356, May 11, 2004.
Fukita et al., “Somatic Hypermutation in the Heavy Chain Locus Correlates with Transcription”, Immunity, vol. 9, pp. 105-114, 1998.
Zan et al., “Induction of Ig Somatic Hypermutation and Class Switching in a Human Monoclonal IgM+IgD+B Cell Line In Vitro: Definition of the Requirements and Modalities of Hypermutation”, The Journal of Immunology, vol. 162, No. 48, pp. 3437-3447, 1999.
Zhou, Cheng et al.; “Human Activation-Induced Cytidine Deaminase is Induced by IL-4 and Negatively Regulated by CD45: Implication of CD45 as a Janus Kinase Phosphatase in Anitbody Diversification”; 2003,Journal of Immunology, vol. 170, pp. 1887-1893.
Tsien Roger Y.
Wang Lei
Duston Jennifer
Sullivan Daniel M.
The Regents of the University of California
Townsend and Townsend / and Crew LLP
LandOfFree
Red-shifted fluorescent proteins mPlum and mRaspberry and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Red-shifted fluorescent proteins mPlum and mRaspberry and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Red-shifted fluorescent proteins mPlum and mRaspberry and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3936443