Red blood cells loaded with S-nitrosothiol and uses therefor

Details Red blood cells loaded with S-nitrosothiol and uses therefor Red blood cells loaded with S-nitrosothiol and uses therefor

2005-07-12

2005-07-12

Witz, Jean C. (Department: 1651)

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Animal or plant cell

C424S093700

Reexamination Certificate

active

06916471

ABSTRACT:
Red blood cells can be loaded with low molecular weight nitrosylating agents, such as S-nitrosothiols, to act as a delivery system for NO+groups to tissues. Loaded red blood cells can be used in methods of therapy for conditions which are characterized by abnormal O2metabolism of tissues, oxygen-related toxicity, abnormal vascular tone, abnormal red blood cell adhesion, or abnormal O2delivery by red blood cells. Such treatment of red blood cells can be extended to in vivo therapies, with the object to achieve an increase in the ratio of red blood cell S-nitrosothiol to hemoglobin.

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