Red blood cell surrogate

Details Red blood cell surrogate Red blood cell surrogate

1994-04-25

1995-11-07

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424491, 424494, 424498, 424450, 514832, A61K 916, A61K 918, A61K 3842

Patent

active

054646340

ABSTRACT:
A red blood cell surrogate which is composed of a nanocrystalline core particle to which an oxygen carrier such as hemoglobin is bound. An oxygen carrier anchor coating is provided between the nanocrystalline core particle and the oxygen carrier in order to provide binding of the oxygen carrier to the nanocrystalline core particle without denaturing the oxygen carrier or otherwise destroying its oxygen carrying capacity. The nanocrystalline core particle with the oxygen carrier bound thereto is coated with a layer of lipid and then an outer layer of a sugar or allosteric effector is applied.

REFERENCES:
patent: 5306508 (1994-04-01), Kossovsky et al.
Loo et al., "Alkaloid Formation in Ergot Sclerotia," Science, vol. 121, Mar. 1955, pp. 367-369.
Lewis, R. W., "Artificial Inoculation of Rye with Ergot. A Susceptible Rye and the Control of Ergot Beetles," J. Am. Pharm. Assoc., Dec. 1948, pp. 511-512.
von Recum, A. F., "Ceramics," Handbook of Biomaterials Evaluation, 1986, pp. 38-54.

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