Red blood cell separation means for specific binding assays

Details Red blood cell separation means for specific binding assays Red blood cell separation means for specific binding assays

1993-05-21

1999-08-17

Spiegel, Carol A.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435 79, 435 792, 435 793, 435 794, 435 795, 435962, 435969, 435970, 436527, 436531, 436535, 436825, G01N 3353

Patent

active

059393319

ABSTRACT:
A method and device for detecting the presence, absence or amount of an analyte in a whole blood sample is disclosed. The device comprises four zones, a sample receiving zone, a labeling zone, a capture zone and an absorbent zone. The sample receiving zone contains an irreversibly immobilized reagent that allows for removal of substantially all red blood cells from the whole blood sample. Flow through the device is via capillary migration and all of the dissolved or dispersed components in the sample flow at substantially equal rates and with relatively unimpaired flow through the device. The method involves the use of the device for detection of analyte in a whole blood sample.

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