Red blood cell filtering system

Liquid purification or separation – Processes – Chemical treatment

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210787, 210806, 210807, 422 41, 422 44, B01D 2126, B01D 2908, B01D 3600

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active

048550639

ABSTRACT:
Closed filtering system for relatively fast and efficient removal of white blood cells from a red blood cell mixture. System comprises at least two blood bags in closed communication with each other via an intermediate filter assembly comprising a housing containing continuous filtering fiber. A preferred housing is tapered and the fiber preferably has a generally Y-shaped cross sectional area and it is adapted to permit substantial removal of white blood cells from a red blood cell mixture with minimal red blood cell hemolysis when the mixture is diluted with perservative solution and passed from one bag to the other at a relatively high flow rate. Filtration is completed within 24 hours, preferably within 6 hours, of whole blood donation.

REFERENCES:
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patent: 4596657 (1986-06-01), Wisdom
patent: 4767541 (1988-08-01), Wisdom
Kleesiek, K. et al., "Elastase from Granulocytes . . . ", Abstract, p. 9-01, 18th Cong. Int. Soc. Blood Transf., Munich, 7/22-27/84.
Jochum, M. et al., "Release of Granulocytic . . . ", Abstract, p. 9-02, 18th Cong. Int. Soc. Blood Transf. Munich, 7/22-27/84.
Kigugawa, K. et al., "Filter Columns . . . ", Vox Sang, vol. 34, pp. 281-290, 1978.
Diepenhorst, P. et al., "Removal of Leukocytes . . . ", Vox Sang, vol. 23, pp. 308-320, 1972.
Diepenhorst, P. et al., "Removal of Leukocytes from Whole Blood . . . ", Vox Sang, vol. 29, pp. 15-22, 1975.
Dern, R. J. et al, "Studies on the Preservation of Human Blood . . . ", J. Lab. Clin. Med., vol. 69, No. 6, pp. 968-978, 1967.
Strehler, Bernard, "Adenosine-5'-Triphosphate . . . ", in Bergmeyer, Editor, 4th Printing, 1974, Acad. Press, N.Y., pp. 2112-2121.

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