Recovery of rare cells using a microchannel apparatus with...

Details Recovery of rare cells using a microchannel apparatus with... Recovery of rare cells using a microchannel apparatus with...

2005-01-18

2011-12-13

Yu, Melanie J (Department: 1641)

Chemistry: molecular biology and microbiology

Apparatus

Including measuring or testing

C435S283100, C435S287100, C435S287200, C435S288700, C436S518000, C422S050000, C422S067000, C422S068100

Reexamination Certificate

active

08076127

ABSTRACT:
A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The posts are spaced across the width of a collection region in the flow path, extending between the upper and lower surfaces thereof; they have rectilinear surfaces, have arcuate cross-sections, and are randomly arranged so as to disrupt streamlined flow. Sequestering agents, such as Abs, are attached to all surfaces in the collection region via a hydrophilic coating, preferably a hydrogel containing isocyanate moieties or a PEG or polyglycine of substantial length, and are highly effective in capturing cells or other targeted biomolecules as a result of such streamlined flow disruption.

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