Recovery of proteinaceous material having reduced nucleic acid l

Details Recovery of proteinaceous material having reduced nucleic acid l Recovery of proteinaceous material having reduced nucleic acid l

1980-08-18

1982-09-07

Schain, Howard E.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

260112R, 426 60, 426 61, 426 62, 426656, 435814, A23J 118

Patent

active

043484794

ABSTRACT:
The present invention relates to a process which comprises recovering proteinaceous materials from nucleoprotein complexes by derivatizing the proteinaceous material with a cyclic anhydride, thereby disassocating the complex, separating the derivatized proteinaceous material from the nucleic acids and subsequently regenerating the proteinaceous material. The recovery of the proteinaceous material is accomplished by maintaining the separated derivatized proteinaceous material at a suitable acidic pH, which is a function of the reaction time and the temperature, until the derivatized proteinaceous material is disassociated into the proteinaceous material and the cyclic anhydride or most usually the equivalent acid and the proteinaceous material is recovered.

REFERENCES:
patent: 3867255 (1975-02-01), Newell et al.
patent: 3903314 (1975-09-01), Chao
patent: 3937693 (1976-02-01), Towersey et al.
patent: 4133904 (1979-01-01), Steer et al.
patent: 4135000 (1979-01-01), Schuldt, Jr.
patent: 4168262 (1979-09-01), Kinsella et al.
patent: 4206243 (1980-06-01), Schlingmann et al.
"Reaction of Proteins with Citraconic Anhydride", by M. Z. Atassi et al., Methods in Enzymology, vol. 25, (1972), pp. 546-553.

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