Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1980-12-29
1982-09-07
Trousof, Natalie
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
562443, 562571, C07C 9912, C07C10352
Patent
active
043483178
ABSTRACT:
There is described an improved process for the separation and recovery of L-phenylalanine and L-aspartic acid from sidestreams resulting from the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester. It has been found that superior separation is obtained by combining one or more of the mother liquor and wash solutions formed during the preparation of .alpha.-L-aspartyl-L-phenylalanine methyl ester, hydrolyzing same to afford the hydrohalide salts of L-aspartic acid and L-phenylalanine, acidifying the hydrolysis solution to precipitate the hydrohalide salt of L-phenylalanine, separating the hydrohalide salt of L-phenylalanine, dissolving it in water and adjusting the pH of the solution to the isoelectric point of L-phenylalanine, thus affording pure L-phenylalanine, and thereafter adjusting the pH of the solution after separation of the L-phenylalanine hydrohalide to the isoelectric point of L-aspartic acid to precipitate L-aspartic acid.
REFERENCES:
patent: 3030380 (1962-04-01), Weygand et al.
patent: 3493602 (1970-02-01), Suranyi et al.
patent: 4173562 (1979-11-01), Bachman et al.
Handbook of Chem. & Phys. 60 Edn., p. C-757 (1979).
Monsanto Company
Reamer James H.
Stanley Howard C.
Trousof Natalie
Wexler Robert E.
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