Recovery of AZT by guanidine precipitation

Details Recovery of AZT by guanidine precipitation Recovery of AZT by guanidine precipitation

1992-07-16

1995-02-07

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

564230, C07H 19073, A61K 3170

Patent

active

053876776

ABSTRACT:
A process for recovering 3'-azido-3'-deoxythymidine (AZT) or a salt thereof from a mixture of chemicals involving the reaction of the AZT with guanidine to form a salt precipitate. The salt precipitate is then acidified to pH of less than about 9 to yield free AZT, which can then be crystallized from solution. 3'-Azido-3'-deoxythymidine and its salts, also known as AZT and Zidovudine, is used in the treatment of AIDS patients.

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