Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1987-07-16
1990-01-16
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530412, 530422, 530425, C07K 326, C07K 328
Patent
active
048944440
ABSTRACT:
Immunologically intact protein or peptide immunogens are recovered from vaccines consisting of immunogen-aluminum hydroxide (alum) complexes. Recovery consists of dissolution of the complexes with an alkali metal salt of a carboxylic acid at a basic pH, reduction of the pH to physiological levels, removal of excess dissolvent and isolation of the protein or peptide immunogen.
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Flaschel, E. et al. "Ultrafiltration for the Separation of Biocatalysts," In: Advances in Biochemical Engineering/Biotechnology (New York, Springer Verlag, 1983), pp. 73, 120, 123.
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Grabner Roy W.
Scattergood Edgar M.
Furman Keith C.
Harbour John W.
Merck & Co. , Inc.
Moskowitz Margaret
Sudol Michael C.
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