Reconstituted surfactants having improved properties

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07897577

ABSTRACT:
The present invention is directed to a reconstituted surfactant containing a lipid carrier, a polypeptide analog of the native surfactant protein SP-C, and a polypeptide comprising a sequence comprised of repeated units where each unit contains between 3 and 8 hydrophobic amino acid residues and one basic amino acid residue. The invention is also directed to the pharmaceutical compositions thereof and to its use for the prophylaxis and/or treatment of RDS and other respiratory disorders.

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Johansson, J., et al., “A Synthetic Surfactant Based on a Poly-Leu SP-C Analog and Phospholipids: Effects on Tidal Volumes and Lung Gas Volumes in Ventilated Immature Newborn Rabbits,” J. Appl. Physiol, vol. 95, Nov. 2003, pp. 2055-2063.
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