Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Glycoprotein – e.g. – mucins – proteoglycans – etc.
Patent
1995-06-07
1998-12-01
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Glycoprotein, e.g., mucins, proteoglycans, etc.
514 12, 514 20, 514 8, 530356, A61K 3710, A61K 3166, A61K 3514, C12N 500
Patent
active
058440984
ABSTRACT:
A reconstituted platelet membrane vesicle preparation is provided. The preparation, directed at promoting hemostasis, may be prepared from proteins and lipids derived from either synthetic sources or from mammalian platelet membranes. The product may be used for transfusions or may be topically applied. Methods for forming the vesicles and products for storing and dispensing the vesicles also are provided.
REFERENCES:
patent: 4731053 (1988-03-01), Hoffman et al.
patent: 4760131 (1988-07-01), Sundsmo et al.
patent: 4871488 (1989-10-01), Mannino et al.
patent: 5185160 (1993-02-01), Chao
patent: 5332578 (1994-07-01), Chao
patent: 5462752 (1995-10-01), Chao
Rybak, M.E., Renzulli, L.A., Bruns,-M.J., Cahaly, D.P., "Platelet Glycoproteins IIb and IIIa as a Calcium Channel in Liposomes", Blood, vol. 72, No. 2 (Aug.), 1988, pp. 714-720.
McGill, M., Fugan, D.A., Vittorio, N., Darrow, C., "Platelet membrane vesicles reduced microvascular bleeding times in thrombocytopenic rabbits", J. Lab. Clin. Med. 1987, 109:127-133.
Rybak, M.E., Linden, H., Zimarowski, M.I., Baca, M., Renzulli, L., "The Plateletsome Immune Lysis Assay (PILA) A New Highly Specific Assay for Autoimmune Thrombocytopenia (ITP)", 1982 Platelets and Megakaryocyes Abstract, p. 473a.
Rybak, M.E., Renzulli, L., "A liposome Based Platelet Substitute, The Plateletsome, with Hemostatic Efficacy", 1983 Platelets and Megakaryocytes Abstract, p. 473a.
Sie, P., Gillois, M., Boneu, B., Chap, H., Bierme, R., Douste-Blazy, L., "Reconstitution of Liposomes Bearing Platelet Receptors for Human von Willebrand Factor", Biochemical and Biophysical Research Communications, 97:133-138 (Nov. 17, 1980).
Baldassare, J.J., Kahn, R.A., Knipp, M.A., Newman, P.J., "Reconstitution of Platelet Proteins into Phospholipid Vesicles", J. Clin. Invest. 75:35-39 (Jan. 1985).
Parise L.V., Phillips, D.R., "Platelet Membrane Glycoprotein IIb-IIIa Complex Incorporated into Phospholipid Vesicles", The Journal of Biological Chemistry 260:1750-1756 (Feb. 1985).
Zucker, M.B., "Can Platelet fragments induce hemostasis?", J. Lab. Clin. Med., 109:111 (1987).
Etemadi, A.-H., "Functional and Orientational Features of Protein Molecules in Reconstituted Lipid Membranes", Advances in Lipid Research 21:281-301 (dates not available).
Jamieson, G.A., Pepper, D.S., "Membrane Glycoproteins of Blood Platelets", The Circulating Platelet pp. 189-205 (1971).
Marcus, A.M., Safier, L.B., Ullman, H.L., "Functions of Platelet Membranes", The Circulating Platelet pp. 241-259 (1971).
Perry, S., Yankee, R.A., "Transfusion and Preservation", The Circulating Platelet pp. 541-551 (1971).
Chao Francis C.
Liang Frank Huayueh
PRP Inc.
Touzeau P. Lynn
Tsang Cecilia J.
LandOfFree
Reconstituted platelet membrane vesicles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Reconstituted platelet membrane vesicles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Reconstituted platelet membrane vesicles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2396725