Recombination-proficient avian/mammalian microcell hybrids

Details Recombination-proficient avian/mammalian microcell hybrids Recombination-proficient avian/mammalian microcell hybrids

1995-03-31

1996-08-06

Budens, Robert D.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4351722, 435 702, 424 933, 935 93, 935 96, 935106, C12N 512, C12N 526, C12N 1508

Patent

active

055433197

ABSTRACT:
An avian/mammalian microcell hybrid immortalized pre B cell line containing a mammalian chromosome that carries a selectable marker has been produced. The avian/mammalian microcell hybrid immortalized pre B cell line can be used for introducing predetermined point mutations into specific mammalian chromosomal loci via high frequency homologous recombination.

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