Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-08-23
2005-08-23
Duffy, Patricia A. (Department: 1645)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069300, C435S071100, C435S320100, C435S006120, C536S023700
Reexamination Certificate
active
06933130
ABSTRACT:
The present invention relates to a method for producing recombinants intended for use in the complete cell-surface protein gp190/MSP1 from plasmodium, especially plasmodium falciparum, as well as the complete DNA sequence of this protein and the appropriate host organisms suited for expressing said sequence, whereby the protein concerned can be entirely synthesized outside the parasite. Also, the inventive method enables sufficient production of above-mentioned protein and its supply as a vaccine. Finally disclosed is a process for stabilizing genes with high At concentration.
REFERENCES:
patent: 0 154 454 (1985-09-01), None
patent: 0 340 359 (1989-11-01), None
patent: 0 359 472 (1990-03-01), None
patent: 0 385 962 (1990-09-01), None
patent: WO 94/28930 (1994-12-01), None
Blackman et al. (Jul. 1990), “A Single Fragment of a Malaria Merozoite Surface Protein Remains on the Parasite During Red Cell Invasion and is the Target of Invasion-inhibiting Antibodies,”J. Exp. Med., vol. 172:379-382.
Chang et al. (Jan. 1996), “A Recombinant Baculovirus 42-Kilodalton C-Terminal Fragment ofPlasmodium falciparumMerozoite Surface Protein 1 Protects Aotus Monkeys Against Malaria,”Infection and Immunity, vol. 64(1):253-261.
Etlinger et al. (Oct. 1991), “Ability of Recombinant or Native Proteins to Protect Monkeys Against Heterologous Challenge withPlasmodium falciparum,”Infection and Immunity, vol. 59(10):3498-3503.
Gentz et al. (1988), “Major Surface Antigen p190 ofPlasmodium falciparum: detection of Common Epitopes Present in a Variety of Plasmodia Isolates,”EMBO Journal, vol. 7(1):225-230.
Gossen et al. (Jun 1992), “Tight Control of Gene Expression in Mammalian Cells by Tetracycline-Responsive Promoters,”Proc. Natl. Acad. Sci. USA, vol. 89:5547-5551.
Hall et al. (Sep. 1984), “Major Surface Antigen Gene of a Human Malaria Parasite Cloned and Expressed in Bacteria,”Nature, vol. 311:379-382.
Heidrich et al. (1989), “The N-Terminal Amino Acid Sequences of thePlasmodium falciparum(FCB1) Merozoite Surface Antigens of 42 and 36 Kilodalton, Both Derived from the 185-195-Kilodalton Precursor,”Mol.&Biochem. Parasitology, vol. 34:147-154.
Herrera et al. (Jan. 1992), “Protection Against Malaria in Aotus Monkeys Immunized with a Recombinant Blood-Stage Antigen Fused to a Unversal T-Cell Epitope: Correlation of Serum Gamma Interferon Levels with Protection,”Infection and Immunity, vol. 60(1):154-158.
Herrera et al. (May 1990), “Immunization of Aotus Monkeys with Plasmodium falciparum Blood-Stage Recombinant Proteins,”Proc. Natl. Acad. Sci. USA, vol. 87:4017-4021.
Holder et al. (1988), “Immunization AgainstPlasmodium falciparumwith Recombinant Polypeptides Produced inEscherichia coli,”Parasite Immunology, vol. 10:607-617.
Holder et al. (Sep. 1985), “Primary Structure of the Precursor to the Three Major Surface Antigens ofPlasmodium falciparumMerozoites,”Nature, vol. 317:270-273.
Holder et al. (Nov. 1981), “Immunization Against Blood-Stage Rodent Malaria Using Purified Parasite Antigens,”Nature, vol. 294:361-364.
Majarian et al. (Jun. 1984), “Passive Immunization Against Murine Malaria with an IgG3 Monoclonal Antibody,”J. of Immunology, vol. 132(6):3131-3137.
Miller et al. (1993), “Analysis of Sequence Diversity in thePlasmodium falciparumMerozoite Surface Protein-1 (MSP-1),”Mol. and Biochem. Parasitology, vol. 59:1-14.
Myler (1989), “Nucleotide and Deducted Amino Acid Sequence of the gp195 (MSA-1) Gene fromPlasmodium falciparum,”Nucleic Acids Research, vol. 17(13):5401.
Pan et al. (1995), “A Direct and Rapid Sequencing Strategy for thePlasmodium falciparumAntigen Gene gp190/MSA1,”Mol. and Biochem. Parasitology, vol. 73:241-244.
Patarroyo et al. (Aug. 1987), “Induction of Protective Immunity Against Experimental Infection with Malaria Using Synthetic Peptides,”Nature, vol. 328:629-632.
Perrin et al. (Aug. 1984), “Antimalarial Immunity in Saimiri Monkeys,”J. Exp. Med., vol. 160:441-451.
Pfefferkorn et al. (1976), “Toxoplasma gondii: Isolation and Preliminary Characterization of Temperature-Sensitive Mutant,”Experimental Parasitology, vol. 39:365-376.
Pirson et al. (Mar. 1985), “Characterization with Monoclonal Antibodies of a Surface Antigen ofPlasmodium falciparumMerozoites,”J. of Immunology, vol. 134(3):1946-1951.
Siddiqui et al. (May 1987), “Merozoite Surface Coat Precursor Protein Completely Protects Aotus Monkeys AgainstPlasmodium falciparumMalaria,”Proc. Natl. Acad. Sci. USA., vol. 84:3014-3018.
Tanabe et al. (1987), “Allelic Dimorphism in a Surface Antigen Gene of the Malaria ParasitePlasmodium falciparum,”J. Mol. Biol., vol. 195:273-287.
Tolle et al. (Jan. 1993), “A Prospective Study of the Association Between the Human Humoral Immune Response toPlasmodium falsiparumBlood Stage Antigen gp190 and Control of Malarial Infections,”Infection and Immunity, vol. 61(1):40-47.
Kaslow et al., (1994), “Expression and Antigenicity ofPlasmodium falsiparumMajor Merozoite Surface Protein (MSP119) Variants Secreted from Saccharomyces cerevisiae,”Molecular and Biochemical Parasitology, vol. 63:283-289.
Bujard Hermann
Pan Weiqing
Tolle Ralf
Borden Paula A.
Bozicevic Field & Francis LLP
Bujard Hermann
Duffy Patricia A.
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