Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1995-04-14
1998-03-10
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435243, 4353201, 435161, 435163, 435165, 435822, 536 232, 536 237, 935 29, 935 60, 935 72, C12N 121, C12N 1574, C12P 706
Patent
active
057260532
ABSTRACT:
The invention relates to microorganisms which normally do not ferment pentose sugar and which are genetically altered to ferment pentose sugar to produce ethanol, and fermentation processes utilizing the same. Examples include Zymomonas mobilis which has been transformed with combinations of E. coli genes for xylose isomerase, xylulokinase, transaldolase, transketolase, L-arabinose isomerase, L-ribulokinase, and L-ribulose-5-phosphate 4-epimerase. Expression of the added genes are under the control of Zymomonas mobilis promoters. These newly created microorganisms are useful for fermenting pentoses and glucose, produced by hydrolysis of hemicellulose and cellulose, to produce ethanol.
REFERENCES:
patent: 5514583 (1996-05-01), Picataggio et al.
S.D. Feldmann et al., "Pentose Metabolism in Zymomonas mobilis Wild-Type and Recombinant Strains", Appl. Microbiol. Biotechnol. 38: 354-361, 1992.
T. Yura et al. "Systematic Sequencing of the Escherichia coli Genome: Analysis of the 0-2.4 min Region", Nuc. Acids Res. (20(13): 3305-3308, Jul. 1992.
G.A. Sprenger, "Aproaches to Broaden the Substrate and Product Range of the Ethanologenic Bacterium Zymomonas mobilis by Genetic Engineering", J. Biotechnol. 27(3) 225-237, Feb. 1993.
N. Lee et al., "The Organization of the araBAD Operon of Escherichia coli", Gene 47: 231-244, 1986.
M.E. Burnett et al., "Molecular Characterization of the Zymomonas mobilis Enolase (eno) Gene", J. Bacteriol. 174(20): 6548-6553, Oct. 1992.
T. Conway et al., "Glyceraldehyde-3-Phosphate Dehydrogenase Gene from Zymomonas mobilis: Cloning, Sequencing and Identification of Promoter Region", J. Bacteriol. 169(12): 5653-5662, Dec. 1987.
C.Q. Lui et al., "Expression of Cloned Xanthomonas D-Xylose Catabolic Genes in Zymomonas mobilis", J. Biotechnol. 7: 61-70, 1988.
Deanda Kristine A.
Eddy Christina K.
Picataggio Stephen K.
Zhang Min
Eure Ruth
Midwest Research Institute
O'Connor Edna M.
Prouty Rebecca E.
Richardson Ken
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