Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving viable micro-organism
Patent
1997-09-24
2000-12-12
Ulm, John
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving viable micro-organism
43525411, C12N 119, C12Q 102
Patent
active
061597058
ABSTRACT:
The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The subject assay enables rapid screening of large numbers of compounds to identify those which act as an agonist or antagonist to the bioactivity of the cellular protein. The subject assay is particularly amenable for identifying surrogate ligands for receptors especially from small molecule or peptide libraries or from peptides produced by an autocrine system.
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Fuernkranz Hans A.
Holmes Scott
Nathan Debra
Paul Jeremy I.
Trueheart Joshua
Cadus Pharmaceutical Corporation
DeConti, Jr. Esq. Giulio A.
Lauro, Esq. Peter C.
Ulm John
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