Recombinant yeast cell and assay using same

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi

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435 15, 435 691, 4352523, 4353201, 435194, 536 232, C12N 114, C12N 1500, C12Q 148, C12P 2106

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059522178

ABSTRACT:
Yeast cell having the ability to express the kinase domain of N-Pak. The expressed kinase domain restores the mating function of a ste20 mutant and such cells are therefore useful in an assay to screen for inhibitors of N-Pak. Such inhibitors may be useful in treatment and/or prevention of Alzheimer's Disease.

REFERENCES:
Bagrodia et al. (1995) J. Biol. Chem. 270;22731-22737.
Murayama et al. (1996) Gerontology 42:2-11.
Bagrodia et al. (1995) J. Biol. Chem. 270:27995-27998.
Brown et al. (1996) Current Biol. 6:598-605.
Cvrckova et al. (1995) Genes & Development 9:1817-1830.
Harden et al. (1996) Mole. and Cell. Biol. pp. 1896-1908.
Knaus et al. (1995) Science 269:221-223.
Kohler et al. (1996) Proc. Natl. Acad. Sci. USA 93:13223-13228.
Leberer et al. (1992) The EMBO Journal 11:4815-4824.
Leberer et al. (1996) Proc. Natl. Acad. Sci. USA 93:13217-13222.
Manser et al. (1994) Nature 367:40-46.
Manser et al. (1995) J. Biol. Chem. 270:25070-25078.
Marcus et al. (1995) Proc. Natl. Acad. Sci. USA 92:6180-6184.
Martin et al. (1995) The EMBO Journal 14:1970-1978.
Mosch et al. (1996) Proc. Natl. Acad. Sci. USA 93:53522-5356.
Ottile et al. (1995) The EMBO Journal 14:5908-5919.
Ramer et al. (1993) Proc. Natl. Acad. Sci. USA 90:452-456.
Teo et al. (1995) J. Biol. Chem. 270:26690-26697.
Wu et al. (1995) J. Biol. Chem. 270:15984-15992.
Zhang et al. (1995) J. Biol. Chem. 270:23934-23936.
Zhao et al. (1995) Mole. and Cell. Biol. 15:5246-5257.

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