Recombinant vesiculoviruses and their uses

Details Recombinant vesiculoviruses and their uses Recombinant vesiculoviruses and their uses

2006-12-26

2006-12-26

Campell, Bruce R. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

C424S224100, C435S005000, C435S069300, C435S173300, C435S235100, C435S236000, C435S239000, C435S242000, C435S320100

Reexamination Certificate

active

07153510

ABSTRACT:
The invention provides recombinant replicable vesiculoviruses. The invention provides a method which, for the first time, successfully allows the production and recovery of replicable vesiculoviruses, as well as recombinant replicable vesiculoviruses, from cloned DNA, by a method comprising expression of the full-length positive-strand vesiculovirus antigenomic RNA in host cells. The recombinant vesiculoviruses do not cause serious pathology in humans, can be obtained in high titers, and have use as vaccines. The recombinant vesiculoviruses can also be inactivated for use as killed vaccines.

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