Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor
Patent
1990-02-15
1993-03-23
Lacey, David L.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Bacteria or actinomycetales; media therefor
435 691, 435 697, 4353201, 530350, C12N 1562, C12N 1531, C12N 1563
Patent
active
051963388
ABSTRACT:
Peptides and proteins related to an epitope comprising an outer membrane protein of Haemophilus influenzae are described. The peptides and proteins can be prepared by methods including novel and improved methods of purification from H. influenzae cultures, and by recombinant DNA and chemical synthetic techniques. Additionally, recombinant vectors containing nucleotide sequences encoding PBOMP-1 and PBOMP-2 related peptides, proteins and fusion proteins are also described. Recombinant vectors include plasmid DNA and viral DNA such as human viruses, animal viruses, insect viruses and bacteriophages that direct the expression of the PBOMP-1 and PBOMP-2 related peptides, proteins, and fusion proteins in appropriate host cells. The peptides, proteins, fusion proteins and viruses both "live" and "inactivated" are used as immunogens in vaccine formulations to protect against H. influenzae infections. The peptides, proteins and fusion proteins are also used as reagents in immunoassays as well as to prepare immunoglobulins for passive immunization. Use of the nucleotide sequences encoding the PBOMP related peptides, proteins and fusion proteins in hybridization assays is also described.
REFERENCES:
patent: 5098997 (1992-03-01), Anilionis et al.
patent: 5110908 (1992-05-01), Deich et al.
Science 222:778-782, Nov. 18, 1983, Young et al., Yeast RNA Polymerase II Genes: Isolation with Antibody Probes.
J. Infect. Diseases 152: 1300-1307, Dec. 1985, Murphy et al., Identification of a Specific Epitope of Haemophilus influenzae on a 16,600 Dalton Outer Membrane Protein.
Bio/Technology 3: 323-326, Apr. 1985, Valenzuela et al., Antigen Engineering in Yeast: Synthesis and Assembly of Hybrid Hepatitis B Surface Antigen-Herpes Simplex 1 gD Particles.
Infect. and Immun. 49: 544-549, Sep. 1985, Munson et al., Purification and Partial Characterization of Outer Membrane Proteins P5 and P6 from Haemophilus influenzae Type b.
Anilionis Algis
Deich Robert A.
Green Bruce A.
Seid, Jr. Robert C.
Zlotnick Gary W.
Baldwin Geraldine F.
Gordon Alan M.
Lacey David L.
Praxis Biologics, Inc.
Ulm John D.
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