Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2007-05-01
2007-05-01
Campell, Bruce R. (Department: 1648)
Chemistry: molecular biology and microbiology
Vector, per se
C435S196000, C424S085100
Reexamination Certificate
active
10406317
ABSTRACT:
The present invention is a recombinant vector encoding and expressing at least three or more costimulatory molecules. The recombinant vector may additionally contain a gene encoding one or more target antigens or immunological epitope thereof. The synergistic effect of these costimulatory molecules on the enhanced activation of T cells is demonstrated. The degree of T-cell activation using recombinant vectors containing genes encoding three costimulatory molecules was far greater than the sum of recombinant vector constructs containing one costimulatory molecule and greater than the use of two costimulatory molecules. Results employing the triple costimulatory vectors were most dramatic under conditions of either low levels of first signal or low stimulator to T-cell ratios. This phenomenon was observed with both isolated CD4+and CD8+T cells. The recombinant vectors of the present invention are useful as immunogenes and vaccines against cancer and pathogenic micro-organisms, and in providing host cells, including dendritic cells and splenocytes with enhanced antigen-presenting functions.
REFERENCES:
patent: 5093258 (1992-03-01), Cohen et al.
patent: 5185146 (1993-02-01), Altenburger
patent: 5738852 (1998-04-01), Robinson et al.
patent: 5891432 (1999-04-01), Hoo
patent: 6045802 (2000-04-01), Schlom et al.
patent: 6241989 (2001-06-01), Scott et al.
patent: 6440422 (2002-08-01), Sutter et al.
patent: WO 9610419 (1996-04-01), None
patent: WO 9610419 (1996-04-01), None
patent: WO 9804727 (1998-02-01), None
Pincus et al. Biologicals, 1995. vol. 23, pp. 159-164.
Hodge et al., “A Trial of Costimulatory Molecules Synergize to Amplify T-cell Activation”, Cancer Research, vol. 59, Nov. 15, 1999, pp. 5800-5807.
Hodge James
Panicali Dennis
Schlom Jeffrey
Campell Bruce R.
Heller Ehrman LLP
Li Bao Qun
The United States of America, as represented by the Secretary, D
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