Recombinant vector and eukaryotic host transformed thereby

Details Recombinant vector and eukaryotic host transformed thereby Recombinant vector and eukaryotic host transformed thereby

1984-09-26

1987-08-11

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

435 68, 435 70, 435235, 435320, 935 6, 935 32, 935 70, C12P 2100, C12N 700, C12N 1500

Patent

active

046861866

ABSTRACT:
A recombinant vector and a eukaryotic host transformed thereby are disclosed. In one embodiment, there is a eukaryotic host that has a recombinant plasmid comprising a plasmid backbone, a foreign eukaryotic gene component, and a first gene segment from a lymphotrophic herpes virus. There is also provided in the host a second gene segment from a lymphotrophic herpes virus. The first and second gene segments interact to assist the plasmid in maintaining itself as a plasmid when inserted into a eukaryotic host, and permit stable replication of the host. The preferred virus is the Epstein-Barr virus, and the two preferred viral segments are the EBV origin of replication and the segment coding for EBNA protein.

REFERENCES:
Yates et al. (1984) Proceedings National Academy of Sciences USA, vol. 81, pp. 3806-3810.
Lusky et al. (1984) Cell, vol. 36, pp. 391-401.
Stow et al. (1983) Nucleic Acids Research, vol. 11, pp. 8205-8220.
Spaete et al. (1982) Cell, vol. 30, pp. 395-304.
Pages 1 and 2 of ATCC Quaterly Newsletter (Jul. 1984), (admitted prior art).
R. C. Mulligan et al., 78 PNAS USA 2072-2076 (1981).

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